RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential
- Authors
- Nam, Seungyoon; Kim, Jung Ho; Lee, Dae Ho
- Issue Date
- 15-May-2019
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- RHOA; gastric cancer; stomach cancer; therapeutics; functions
- Citation
- FRONTIERS IN GENETICS, v.10
- Journal Title
- FRONTIERS IN GENETICS
- Volume
- 10
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1491
- DOI
- 10.3389/fgene.2019.00438
- ISSN
- 1664-8021
- Abstract
- The well-known signal mediator and small GTPase family member, RHOA, has now been associated with the progression of specific malignancies. In this review, we appraise the biomedical literature regarding the role of this enzyme in gastric cancer (GC) signaling, suggesting potential clinical significance. To that end, we examined RHOA activity, with regard to second-generation hallmarks of cancer, finding particular association with the hallmark "activation of invasion and metastasis." Moreover, an abundance of studies show RHOA association with Lauren classification diffuse subtype, in addition to poorly differentiated GC. With regard to therapeutic value, we found RHOA signaling to influence the activity of specific widely used chemotherapeutics, and its possible antagonism by various dietary constituents. We also review currently available targeted therapies for GC. The latter, however, showed a paucity of such agents, underscoring the urgent need for further investigation into treatments for this highly lethal malignancy.
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Collections - 의과대학 > 의학과 > 1. Journal Articles
- 바이오나노대학 > 생명과학과 > 1. Journal Articles
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