New bis-thioglycosyl-1,1 '-disulfides from Nasturtium officinale R. Br. and their anti-neuroinflammatory effect
DC Field | Value | Language |
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dc.contributor.author | Lee, Tae Hyun | - |
dc.contributor.author | Khan, Zahra | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.available | 2020-02-27T03:41:19Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1507 | - |
dc.description.abstract | As a part of our continuing search for bioactive constituents from Brassicaceae family, three new bis-thioglycosides (1-3) were isolated from the 80% MeOH extract of Nasturtium officinale, together with 13 known compounds (4-16). The chemical structures of three new bis-thioglycosides (1-3) were elucidated using NMR techniques (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, and HMBC), HRESIMS, and a chemical method. All the compounds were evaluated for their inhibitory effects on nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Among the isolates, compound 5 exhibited a strong inhibitory effect on NO production, and compounds 4 and 15 showed moderate inhibitory activities, suggesting the neuroprotective and anti-neuroinflammatory effects of bis-thioglycosides from N. officinale. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOORGANIC CHEMISTRY | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | BIOLOGICAL EVALUATION | - |
dc.subject | (R-S)-GLUCORAPHANIN | - |
dc.subject | ISOTHIOCYANATES | - |
dc.subject | CONSTITUENTS | - |
dc.subject | DYSFUNCTION | - |
dc.subject | WATERCRESS | - |
dc.subject | PATTERN | - |
dc.subject | ROOTS | - |
dc.subject | MODEL | - |
dc.title | New bis-thioglycosyl-1,1 '-disulfides from Nasturtium officinale R. Br. and their anti-neuroinflammatory effect | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000464108100053 | - |
dc.identifier.doi | 10.1016/j.bioorg.2019.01.062 | - |
dc.identifier.bibliographicCitation | BIOORGANIC CHEMISTRY, v.86, pp.501 - 506 | - |
dc.identifier.scopusid | 2-s2.0-85061525140 | - |
dc.citation.endPage | 506 | - |
dc.citation.startPage | 501 | - |
dc.citation.title | BIOORGANIC CHEMISTRY | - |
dc.citation.volume | 86 | - |
dc.contributor.affiliatedAuthor | Khan, Zahra | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Nasturtium officinale | - |
dc.subject.keywordAuthor | Brassicaceae | - |
dc.subject.keywordAuthor | Bis-thioglycosides | - |
dc.subject.keywordAuthor | Anti-neuroinflammation | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | (R-S)-GLUCORAPHANIN | - |
dc.subject.keywordPlus | ISOTHIOCYANATES | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | WATERCRESS | - |
dc.subject.keywordPlus | PATTERN | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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