New bis-thioglycosyl-1,1 '-disulfides from Nasturtium officinale R. Br. and their anti-neuroinflammatory effect
- Authors
- Lee, Tae Hyun; Khan, Zahra; Subedi, Lalita; Kim, Sun Yeou; Lee, Kang Ro
- Issue Date
- May-2019
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Nasturtium officinale; Brassicaceae; Bis-thioglycosides; Anti-neuroinflammation; Microglia
- Citation
- BIOORGANIC CHEMISTRY, v.86, pp.501 - 506
- Journal Title
- BIOORGANIC CHEMISTRY
- Volume
- 86
- Start Page
- 501
- End Page
- 506
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1507
- DOI
- 10.1016/j.bioorg.2019.01.062
- ISSN
- 0045-2068
- Abstract
- As a part of our continuing search for bioactive constituents from Brassicaceae family, three new bis-thioglycosides (1-3) were isolated from the 80% MeOH extract of Nasturtium officinale, together with 13 known compounds (4-16). The chemical structures of three new bis-thioglycosides (1-3) were elucidated using NMR techniques (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC, and HMBC), HRESIMS, and a chemical method. All the compounds were evaluated for their inhibitory effects on nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Among the isolates, compound 5 exhibited a strong inhibitory effect on NO production, and compounds 4 and 15 showed moderate inhibitory activities, suggesting the neuroprotective and anti-neuroinflammatory effects of bis-thioglycosides from N. officinale.
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