병원획득 Extended-spectrum ß-Lactamase 생성 Escherichia coli 균혈증의 위험인자Risk Factors of Nosocomial Bacteremia of Extended-spectrum β-Lactamase Producing Escherichia coli
- Other Titles
- Risk Factors of Nosocomial Bacteremia of Extended-spectrum β-Lactamase Producing Escherichia coli
- Authors
- 고대식; 문송미; 이지성; 박윤수; 조용균
- Issue Date
- Dec-2013
- Publisher
- 영남대학교 의과대학
- Keywords
- Extended-spectrum β-lactamase; Escherichia coli; Nosocomial; Bacteremia
- Citation
- Yeungnam University Journal of Medicine, v.30, no.2, pp.83 - 89
- Journal Title
- Yeungnam University Journal of Medicine
- Volume
- 30
- Number
- 2
- Start Page
- 83
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15103
- ISSN
- 2384-0293
- Abstract
- Background: The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is increasing rapidly worldwide. Treatment options for ESBL-producing E. coli are limited, and infections caused by this organism are associated with improper antibiotic use, a long hospital stay, and increased mortality.
Thus, the assessment and early recognition of the risk factors of nosocomial infections due to ESBL-producing E. coli are important for the infection control and proper treatment.
Methods: A case-control study was performed that included nosocomial episodes of ESBL-producing E.
coli bacteremia at a tertiary care hospital from January 2004 to December 2007. For each case patient, three controls were randomly selected and data on predisposing factors were collected.
Results: Fifty-five cases of nosocomial ESBL-producing E. coli bacteremia were studied. Carbapenem usage (OR: 11.3, 95% CI: 1.1-115.9, p=0.041), quinolone usage (OR: 4.5, 95% CI: 1.1-18.8, p=0.042), biliary obstructive disease (OR: 11.8, 95% CI: 3.0-46.7, p<0.001) and the APACHE II score (OR: 1.3, 95% CI: 1.2- 1.5, p<0.001) were analyzed as independent risk factors of nosocomial ESBL-producing E. coli bacteremia.
Conclusion: Our results showed that physicians caring for patients with risk factors of nosocomial bacteremia should consider ESBL-producing E. coli as the causative organisms of the disease.
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