PCL 생분해성 고분자 그라프트를 위한 다양한 하이드록시기도입에 의한 스테인레스 스틸의 표면개질

Abstract

The metallic (stainless steel; SS) biomaterials have been utilized for vascular interventional devices such as stents and vena cava filters. However, thrombosis, inflammation, and restenosis that are associated with implants are still major obstacles for the use of these devices. To improve biocompatibility of SS metal, biodegradable poly(ε-caprolactone)(PCL) polymer-grafted SS plates were investigated by surface-initiated ring-opening polymerization (SI-ROP) of ε-caprolactone. For SI-ROP, surface-functionalized SS was prepared with different hydroxyl derivatives such as L-lactic acid (L),L-serine (S), and ricinoleic acid (RA). The physicochemical properties of surface-modified SS were evaluated. Obtained results exhibited that the surface morphology and properties of SS plates were depending on hydroxyl derivatives as well as the degree of polymerization and polymer grafting density. In particular, RA-coupled SS was greatly attributed to increased PCL grafting to the surface and therefore, this biodegradable PCL-grafted SS is expected to be useful for surface-modified implants including stents.