Meta-analysis: Sequential Therapy Is Superior to Conventional Therapy for Helicobacter pylori Infection in Korea메타분석: 한국에서 Helicobacter pylori 제균에 순차치료가 기존치료보다 우월하다
- Other Titles
- 메타분석: 한국에서 Helicobacter pylori 제균에 순차치료가 기존치료보다 우월하다
- Authors
- 정준원; 하민수; 윤성철; 김정호; 이종준; 김윤재; 김경오; 권광안; 박동균; 이동호
- Issue Date
- Nov-2013
- Publisher
- 대한소화기학회
- Keywords
- Helicobacter pylori; Sequential therapy; Meta-analysis
- Citation
- 대한소화기학회지, v.62, no.5, pp.267 - 271
- Journal Title
- 대한소화기학회지
- Volume
- 62
- Number
- 5
- Start Page
- 267
- End Page
- 271
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15236
- DOI
- 10.4166/kjg.2013.62.5.267
- ISSN
- 1598-9992
- Abstract
- ackground/Aims: Conventional triple therapy (CT) for Helicobacter pylori infection fails in up to one-third of patients. Sequential therapy (ST) seem be more effective than CT in other countries. However, there is no systemic literature review that directly compares CT and ST in Korea. The aim of this study was to compare ST with CT for H. pylori infection in Korea.
Methods: Six randomized, prospective controlled trials were used to compare 10-day ST and 7- to 14-day CT in treatment-naive patients with documented H. pylori infection in Korea. Pooled eradication rates and OR with 95% CI were calculated.
Results: The intention-to-treat eradication rates of H. pylori involving 1,529 patients were 79.7% (95% CI, 76.8-82.5%) for ST (n=754) and 68.1% (95% CI, 64.8-71.4%) for CT (n=775) (OR, 1.838; p<0.001). The per-protocol eradication rate of H. pylori involving 1,366 patients was 86.4% (95% CI, 83.3-88.5%) for ST (n=682) and 76.0% (95% CI, 72.8-79.2%) for CT (n=684) (OR, 1.974; p<0.001).
Conclusions: Ten-day ST was superior to CT in terms of eradicating H. pylori infection. Therefore, ST should be considered as a first-line therapy in Korea. However, ST did not achieve a sufficient eradication rate. More effective therapy should be developed.
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