예방 약물 치료 기간이 통풍 재발에 미치는 영향Duration of Prophylactic Therapy Affects the Frequency of Gout Flare
- Other Titles
- Duration of Prophylactic Therapy Affects the Frequency of Gout Flare
- Authors
- 최효진; 신승각; 서미령; 류희정; 백한주
- Issue Date
- 2013
- Publisher
- 대한류마티스학회
- Keywords
- Prophylactic duration; Gout flare; Urate lowering treatment
- Citation
- 대한류마티스학회지, v.20, no.1, pp.17 - 23
- Journal Title
- 대한류마티스학회지
- Volume
- 20
- Number
- 1
- Start Page
- 17
- End Page
- 23
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15814
- ISSN
- 2093-940X
- Abstract
- Objective. To evaluate the effect of prophylactic therapy on gout flare during urate lowering treatment.
Methods. We retrospectively examined the data derived from 59 patients who had been treated with allopurinol for more than six months after stopping prophylactic medication at our rheumatology clinic. Demographic data (age, sex, disease duration, tophi and comorbidity), clinical and laboratory features, including presence of gout flare during urate lowering treatment, dose of allopurinol, serum uric acid level and creatinine clearance at initiation and six months later, were collected. For the subgroup analysis, the same data were collected in 46 patients who had been followed up at one year after stopping prophylactic medication.
Results. Twenty-eight patients among 59 (47.4%) had experienced at least 1 gouty attack during urate lowering therapy. The mean duration of prophylactic medication was not different between the flare group (3.8 months) and the non- flare group (5.9 months, p=0.617). Six months later, the mean serum uric acid level was 6.3 mg/dL (6.1 mg/dL vs. 6.5 mg/dL). According to the duration of prophylactic treatment (<6 months, ≥6 months), there were more frequent flares in the <6 months group than in the ≥6 months group (51.2% vs. 38.9% in the six month follow- up group, 70.6% vs. 50% in the one year follow-up group).
Conclusion. Prophylactic medication for more than six months could be a favorable factor for the prevention of recurrent gout flare during urate lowering treatment.
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