Water-stable single-walled carbon nanotubes coated by pyrenyl polyethylene glycol for fluorescence imaging and photothermal therapy
- Authors
- Jang, Kuewhan; Eom, Kilho; Lee, Gyudo; Han, Jae-Hee; Haam, Seungjoo; Yang, Jaemoon; Kim, Eunseon; Kim, Woo-Jae; Kwon, Taeyun
- Issue Date
- Dec-2012
- Publisher
- KOREAN BIOCHIP SOCIETY-KBCS
- Keywords
- Single-walled carbon nanotube; Pyrenyl group; Polyethylene glycol; Fluorescence imaging agent; Photothermal therapy
- Citation
- BIOCHIP JOURNAL, v.6, no.4, pp.396 - 403
- Journal Title
- BIOCHIP JOURNAL
- Volume
- 6
- Number
- 4
- Start Page
- 396
- End Page
- 403
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15956
- DOI
- 10.1007/s13206-012-6412-0
- ISSN
- 1976-0280
- Abstract
- Nanomaterials have recently received significant attention as photothermal agents and fluorescence contrast agents for molecular therapeutics due to their unique optical properties (e.g. light absorption). In particular, single-walled carbon nanotubes (SWNTs) have been recently utilized as photothermal agents (for photothermal therapy) because of the solubility of SWNTs as well as their light absorbing capability at the near-infrared region. In this work, we have developed the SWNT-based photothermal agents using pyrene-based PEGylation of SWNTs. FT-IR and/or H-NMR spectroscopies have validated the PEGylation of SWNTs, and it is shown that water-soluble SWNTs are able to generate heat under near-infrared (NIR) irradiation of 5W/cm(2). Moreover, it is found that our pyrene-based PEGylated SWNTs exhibit the fluorescence characteristic under the excitation wavelength of 340 nm. Our study sheds light on the pyrenyl PEGylated SWNTs as photothermal agents and/or fluorescence contrast agents for the future applications in molecular therapeutics.
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