5-HT1A receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia
DC Field | Value | Language |
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dc.contributor.author | Jung, Yang-Hee | - |
dc.contributor.author | Kwon, Seung-Hwan | - |
dc.contributor.author | Hong, Sa-Ik | - |
dc.contributor.author | Lee, Sung-Ok | - |
dc.contributor.author | Kim, Sun-Yeou | - |
dc.contributor.author | Lee, Seok-Yong | - |
dc.contributor.author | Jang, Choon-Gon | - |
dc.date.available | 2020-02-29T04:44:57Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-12 | - |
dc.identifier.issn | 0091-3057 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15976 | - |
dc.description.abstract | Previously we reported that the 50% EtOH extract of Cinnamomum cassia (C. cassia) possesses anxiolytic-like activity in the mouse elevated plus maze (EPM) test. This activity was blocked by the 5-HT1A receptor antagonist, WAY 100635. Therefore, in order to investigate the effect of C. cassia on 5-HT1A receptor binding, quantitative autoradiography of 5-HT1A receptors was carried out in brains of mice treated acutely and repeatedly with C. cassia. Binding of [H-3]8-OH-DPAT to the 5-HT1A receptor was investigated in the mouse brain. After a single treatment of C. cassia (750 mg/kg, p.o.), [H-3]8-OH-DPAT binding showed a significant increase in the dorsal raphe nucleus (DRN). After repeated treatment with C. cassia (100 mg/kg, once a day for 5 days. p.o.), [H-3]8-OH-DPAT binding showed no significant change in any brain region. Taken together, the anxiolytic-like effect of the 50% EtOH extract of C. cassia might be mediated by region specific change of 5-HT1A receptors in the dorsal raphe nucleus. (C) 2012 Published by Elsevier Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | - |
dc.subject | AUTORECEPTOR SENSITIVITY | - |
dc.subject | AGONISTS | - |
dc.subject | SEROTONIN | - |
dc.subject | STRESS | - |
dc.subject | IPSAPIRONE | - |
dc.subject | BUSPIRONE | - |
dc.subject | RESPONSES | - |
dc.subject | 8-OH-DPAT | - |
dc.subject | GEPIRONE | - |
dc.subject | EXTRACT | - |
dc.title | 5-HT1A receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000312350200029 | - |
dc.identifier.doi | 10.1016/j.pbb.2012.09.004 | - |
dc.identifier.bibliographicCitation | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, v.103, no.2, pp.367 - 372 | - |
dc.identifier.scopusid | 2-s2.0-84866853253 | - |
dc.citation.endPage | 372 | - |
dc.citation.startPage | 367 | - |
dc.citation.title | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | - |
dc.citation.volume | 103 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kim, Sun-Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Receptor binding autoradiography | - |
dc.subject.keywordAuthor | 5-HT1A receptor | - |
dc.subject.keywordAuthor | Anxiolytic-like effect | - |
dc.subject.keywordAuthor | Cinnamomum cassia | - |
dc.subject.keywordPlus | AUTORECEPTOR SENSITIVITY | - |
dc.subject.keywordPlus | AGONISTS | - |
dc.subject.keywordPlus | SEROTONIN | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | IPSAPIRONE | - |
dc.subject.keywordPlus | BUSPIRONE | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | 8-OH-DPAT | - |
dc.subject.keywordPlus | GEPIRONE | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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