5-HT1A receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia
- Authors
- Jung, Yang-Hee; Kwon, Seung-Hwan; Hong, Sa-Ik; Lee, Sung-Ok; Kim, Sun-Yeou; Lee, Seok-Yong; Jang, Choon-Gon
- Issue Date
- Dec-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Receptor binding autoradiography; 5-HT1A receptor; Anxiolytic-like effect; Cinnamomum cassia
- Citation
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, v.103, no.2, pp.367 - 372
- Journal Title
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Volume
- 103
- Number
- 2
- Start Page
- 367
- End Page
- 372
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/15976
- DOI
- 10.1016/j.pbb.2012.09.004
- ISSN
- 0091-3057
- Abstract
- Previously we reported that the 50% EtOH extract of Cinnamomum cassia (C. cassia) possesses anxiolytic-like activity in the mouse elevated plus maze (EPM) test. This activity was blocked by the 5-HT1A receptor antagonist, WAY 100635. Therefore, in order to investigate the effect of C. cassia on 5-HT1A receptor binding, quantitative autoradiography of 5-HT1A receptors was carried out in brains of mice treated acutely and repeatedly with C. cassia. Binding of [H-3]8-OH-DPAT to the 5-HT1A receptor was investigated in the mouse brain. After a single treatment of C. cassia (750 mg/kg, p.o.), [H-3]8-OH-DPAT binding showed a significant increase in the dorsal raphe nucleus (DRN). After repeated treatment with C. cassia (100 mg/kg, once a day for 5 days. p.o.), [H-3]8-OH-DPAT binding showed no significant change in any brain region. Taken together, the anxiolytic-like effect of the 50% EtOH extract of C. cassia might be mediated by region specific change of 5-HT1A receptors in the dorsal raphe nucleus. (C) 2012 Published by Elsevier Inc.
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