Increased Plasma Osmolar Gap Is Predictive of Contrast-Induced Acute Kidney Injury
- Authors
- Kim, Sejoong; Sung, Jiyoon; Kang, Woong Chul; Ahn, Shin Young; Kim, Dong Ki; Chin, Ho Jun; Na, Ki Young; Joo, Kwon Wook; Chae, Dong-Wan; Han, Jin Suk
- Issue Date
- Oct-2012
- Publisher
- TOHOKU UNIV MEDICAL PRESS
- Keywords
- acute kidney injury; biomarker; contrast media; coronary angiography; osmolality
- Citation
- TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, v.228, no.2, pp.109 - 117
- Journal Title
- TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
- Volume
- 228
- Number
- 2
- Start Page
- 109
- End Page
- 117
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16090
- DOI
- 10.1620/tjem.228.109
- ISSN
- 0040-8727
- Abstract
- Contrast-induced acute kidney injury (CIAKI) is a common complication after percutaneous coronary artery intervention (PCI). It is urgent to find a novel, easily measurable and accurate predictor for the early detection of CIAKI. Hyperosmolarity and large amounts of contrast media are risk factors for CIAKI. However, there is no study on plasma osmolar gap as a predictor of CIAKI. We enrolled 89 patients undergoing elective PCI and tested changes of serum sodium, osmolar gap, and renal function at 0, 6, 12 and 24 hours. Plasma osmolar gap was calculated using the following formula: measured plasma osmolarity - [2(Na) + serum urea nitrogen/2.8 + glucose/18]. CIAKI was defined as follows: increase in serum creatinine of >= 50%, increase in serum creatinine of >= 0.3 mg/dL, or decrease in estimated glomerular filtration rate of >= 25% within 24 hours after PCI. The incidence of CIAKI was 13.5% (12/89 patients). The CIAKI group had higher plasma osmolar gaps 6 hours after PCI. The adjusted hazard ratio of the plasma osmolar gap from hour 6 (1-mOsm/L increments) to the development of CIAKI was 1.12 (95% confidence interval [CI], 1.01-1.26; P = 0.041). Sensitivity and specificity of 7 mOsm/L or higher plasma osmolar gap at hour 6 were 70.0% and 76.6%, respectively (area under the ROC curve = 0.77 [95% Cl, 0.65-0.89]). Increased plasma osmolar gap may precede the development of CIAKI in patients undergoing PCI. In conclusion, plasma osnnolar gap may be a useful predictor for the development of CIAKI.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16090)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.