Enhanced delivery of T cells to tumor after chemotherapy using membrane-anchored, apoptosis-targeted peptide
DC Field | Value | Language |
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dc.contributor.author | He, Xiaofeng | - |
dc.contributor.author | Bonaparte, Napolean | - |
dc.contributor.author | Kim, Soyoun | - |
dc.contributor.author | Acharya, Bodhraj | - |
dc.contributor.author | Lee, Ji-Young | - |
dc.contributor.author | Chi, Lianhua | - |
dc.contributor.author | Lee, Hyoung-Joo | - |
dc.contributor.author | Paik, Young-Ki | - |
dc.contributor.author | Moon, Pyong-Gon | - |
dc.contributor.author | Baek, Moon-Chang | - |
dc.contributor.author | Lee, Eun-Kyu | - |
dc.contributor.author | Kim, Jong-Ho | - |
dc.contributor.author | Kim, In-San | - |
dc.contributor.author | Lee, Byung-Heon | - |
dc.date.available | 2020-02-29T05:43:10Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16161 | - |
dc.description.abstract | Chemotherapy-induced apoptosis of tumor cells enhances the antigen presentation and sensitizes tumor cells to T cell-mediated cytotoxicity. Here we harnessed the apoptosis of tumor cells as a homing signal for the delivery of T cells to tumor. Jurkat T cells were anchored with ApoPep-1, an apoptosis-targeted peptide ligand, using the biocompatible anchor for membrane (BAM), an oleyl acid derivative. The ApoPep-1-BAM conjugate was efficiently anchored to cell membrane, while little anchoring was obtained with ApoPep-1 alone. The retention period of the ApoPep-1-BAM conjugate on cell membrane was approximately 80 and 40 min in the absence and presence of serum, respectively. ApoPep-1 was resistant to degradation in serum until 2 h. The apoptosis-targeted T cells that were anchored with the ApoPep-1-BAM preferentially bound to apoptotic tumor cells over living cells. When intravenously injected into tumor-bearing mice, the number of apoptosis-targeted T cells and in vivo fluorescence signals by the homing of the cells to doxorubicin-treated tumor were higher than those of untargeted T cells. Accumulation of apoptosis-targeted T cells at other organs such as liver was not detected. These results suggest that the chemotherapy-induced apoptosis and subsequent enhancement of T cell delivery to tumor by the membrane anchoring of the apoptosis-targeted peptide could be a novel strategy for cancer immunotherapy. (C) 2012 Elsevier B. V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF CONTROLLED RELEASE | - |
dc.title | Enhanced delivery of T cells to tumor after chemotherapy using membrane-anchored, apoptosis-targeted peptide | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000310506900005 | - |
dc.identifier.doi | 10.1016/j.jconrel.2012.07.023 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CONTROLLED RELEASE, v.162, no.3, pp.521 - 528 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84865609692 | - |
dc.citation.endPage | 528 | - |
dc.citation.startPage | 521 | - |
dc.citation.title | JOURNAL OF CONTROLLED RELEASE | - |
dc.citation.volume | 162 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Eun-Kyu | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Biological anchor for membrane | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Peptide | - |
dc.subject.keywordAuthor | T cell delivery | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | SOLID TUMOR | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | NUCLEOSOMES | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | EXPOSURE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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