Effect of Anti-Siglec-F Antibody and Reactive Oxygen Species Blocking on Histamine Release in Urinary Bladder of Ovalbumin-Treated Mice
DC Field | Value | Language |
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dc.contributor.author | Choi, Bo-Hwa | - |
dc.contributor.author | Choo, Gwoan-Youb | - |
dc.contributor.author | Kang, Ju-Hee | - |
dc.contributor.author | Lee, Choong-Yeol | - |
dc.contributor.author | Park, Chang-Shin | - |
dc.date.available | 2020-02-29T05:43:36Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 2093-4777 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16185 | - |
dc.description.abstract | Purpose: Sialic acid-binding Ig-like lectin (Siglec) is an immune inhibitory receptor that plays a role in the negative regulation of the activation of immune cells. This study aimed to evaluate the effects of anti-Siglec-F on plasma and urinary histamine levels in ovalbumin (OVA)-challenged urinary bladder in mice. Methods: Thirty BALB/c mice were used. In group I (control group, n = 5), mice were sensitized with OVA and challenged with saline. In group II (OVA challenge group, n = 5), OVA was used for intraperitoneal sensitization and intravesical challenge. The challenged mice in group III (control immunoglobulin G [IgG] group, n = 5) and those in group IV (anti-Siglec-F group, n = 5) were intraperitoneally pretreated with rabbit control IgG or anti-Siglec-F antibody, respectively. In groups V (N-acetylcysteine [NAC] in OVA challenge group, n = 5) and VI (control NAC only, n = 5), mice were pretreated with NAC. Results: Urinary histamine concentrations were significantly higher 7 days after intravesical OVA challenge (P < 0.01), whereas plasma histamine levels were not. Pretreatment with anti-Siglec-F antibody significantly prevented the increase in urinary histamine release (P < 0.05), whereas pretreatment with the IgG antibody control did not. Also, pretreatment of the OVA challenge group with NAC did not affect the histamine concentration in either urine or plasma. Conclusions: Systemic anti-Siglec-F treatment showed anti-allergic effects at least on local histamine release, particularly in the lower urinary bladder. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CONTINENCE SOC | - |
dc.relation.isPartOf | INTERNATIONAL NEUROUROLOGY JOURNAL | - |
dc.title | Effect of Anti-Siglec-F Antibody and Reactive Oxygen Species Blocking on Histamine Release in Urinary Bladder of Ovalbumin-Treated Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000209007500005 | - |
dc.identifier.doi | 10.5213/inj.2012.16.3.122 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL NEUROUROLOGY JOURNAL, v.16, no.3, pp.122 - 125 | - |
dc.identifier.kciid | ART001702540 | - |
dc.identifier.scopusid | 2-s2.0-84873434599 | - |
dc.citation.endPage | 125 | - |
dc.citation.startPage | 122 | - |
dc.citation.title | INTERNATIONAL NEUROUROLOGY JOURNAL | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Choong-Yeol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Histamine | - |
dc.subject.keywordAuthor | Mice | - |
dc.subject.keywordAuthor | Ovalbumin | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Sialic acid binding Ig-like lectin | - |
dc.subject.keywordAuthor | Urinary bladder | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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