CMOS Image Sensor-based Immunodetection by Refractive-Index Change
DC Field | Value | Language |
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dc.contributor.author | Devadhasan, Jasmine P. | - |
dc.contributor.author | Kim, Sanghyo | - |
dc.date.available | 2020-02-29T05:44:21Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0910-6340 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16214 | - |
dc.description.abstract | A complementary metal oxide semiconductor (CMOS) image sensor is an intriguing technology for the development of a novel biosensor. Indeed, the CMOS image sensor mechanism concerning the detection of the antigen-antibody (Ag-Ab) interaction at the nanoscale has been ambiguous so far. To understand the mechanism, more extensive research has been necessary to achieve point-of-care diagnostic devices. This research has demonstrated a CMOS image sensor-based analysis of cardiovascular disease markers, such as C-reactive protein (CRP) and troponin I, Ag-Ab interactions on indium nanoparticle (InNP) substrates by simple photon count variation. The developed sensor is feasible to detect proteins even at a fg/mL concentration under ordinary room light. Possible mechanisms, such as dielectric constant and refractive-index changes, have been studied and proposed. A dramatic change in the refractive index after protein adsorption on an InNP substrate was observed to be a predominant factor involved in CMOS image sensor-based immunoassay. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | JAPAN SOC ANALYTICAL CHEMISTRY | - |
dc.relation.isPartOf | ANALYTICAL SCIENCES | - |
dc.subject | PROTEIN ADSORPTION | - |
dc.subject | ASSAY | - |
dc.subject | DNA | - |
dc.title | CMOS Image Sensor-based Immunodetection by Refractive-Index Change | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309333000007 | - |
dc.identifier.bibliographicCitation | ANALYTICAL SCIENCES, v.28, no.9, pp.875 - 880 | - |
dc.identifier.scopusid | 2-s2.0-84867381269 | - |
dc.citation.endPage | 880 | - |
dc.citation.startPage | 875 | - |
dc.citation.title | ANALYTICAL SCIENCES | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Devadhasan, Jasmine P. | - |
dc.contributor.affiliatedAuthor | Kim, Sanghyo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN ADSORPTION | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | DNA | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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