CMOS Image Sensor-based Immunodetection by Refractive-Index Change
- Authors
- Devadhasan, Jasmine P.; Kim, Sanghyo
- Issue Date
- Sep-2012
- Publisher
- JAPAN SOC ANALYTICAL CHEMISTRY
- Citation
- ANALYTICAL SCIENCES, v.28, no.9, pp.875 - 880
- Journal Title
- ANALYTICAL SCIENCES
- Volume
- 28
- Number
- 9
- Start Page
- 875
- End Page
- 880
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16214
- ISSN
- 0910-6340
- Abstract
- A complementary metal oxide semiconductor (CMOS) image sensor is an intriguing technology for the development of a novel biosensor. Indeed, the CMOS image sensor mechanism concerning the detection of the antigen-antibody (Ag-Ab) interaction at the nanoscale has been ambiguous so far. To understand the mechanism, more extensive research has been necessary to achieve point-of-care diagnostic devices. This research has demonstrated a CMOS image sensor-based analysis of cardiovascular disease markers, such as C-reactive protein (CRP) and troponin I, Ag-Ab interactions on indium nanoparticle (InNP) substrates by simple photon count variation. The developed sensor is feasible to detect proteins even at a fg/mL concentration under ordinary room light. Possible mechanisms, such as dielectric constant and refractive-index changes, have been studied and proposed. A dramatic change in the refractive index after protein adsorption on an InNP substrate was observed to be a predominant factor involved in CMOS image sensor-based immunoassay.
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