Association with tryptophan hydroxylase 2 gene polymorphisms and autism spectrum disorders in Korean families
- Authors
- Yang, So Young; Yoo, Hee Jeong; Cho, In Hee; Park, Mira; Kim, Soon Ae
- Issue Date
- Aug-2012
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Tryptophan hydroxylase 2 gene; Autism spectrum disorder; Single nucleotide polymorphism; Association
- Citation
- NEUROSCIENCE RESEARCH, v.73, no.4, pp.333 - 336
- Journal Title
- NEUROSCIENCE RESEARCH
- Volume
- 73
- Number
- 4
- Start Page
- 333
- End Page
- 336
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16240
- DOI
- 10.1016/j.neures.2012.05.012
- ISSN
- 0168-0102
- Abstract
- It was performed a family-based association study of 6 single nucleotide polymorphisms (SNPs) from the TPH2 with autism spectrum disorder (ASD) in 151 Korean trios. We found a significant association at the rs2129575 with ASD susceptibility (corrected p = 0.006). Furthermore, after conducting with the quantitative scores in the Autism Diagnostic Interview-Revised, there were associations between restricted, repetitive, and stereotyped patterns of behavior (preoccupation with parts of objects or nonfunctional elements of materials) in ASD and SNPs in TPH2. These results suggest that TPH2 polymorphisms influence the phenotypic impairments of ASD and enhance ASD susceptibility. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16240)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.