Asian Sand Dust Enhances Allergen-Induced Th2 Allergic Inflammatory Changes and Mucin Production in BALB/c Mouse Lungs
DC Field | Value | Language |
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dc.contributor.author | Kang, Il Gyu | - |
dc.contributor.author | Jung, Joo Hyun | - |
dc.contributor.author | Kim, Seon Tae | - |
dc.date.available | 2020-02-29T05:46:43Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16309 | - |
dc.description.abstract | Purpose: Recent studies have reported that Asian sand dust (ASD) has a potential risk of aggravating airway inflammation. The purpose of this study was to investigate the effect of ASD on inflammation and mucin production in the airways of allergic mice. Methods: Forty BALB/c female mice were divided into four groups: saline (group 1); ASD (group 2); ovalbumin (OVA) alone (group 3); and OVA+ASD (group 4). OVA-specific immunoglobulin E (IgE) in serum and interleukin (IL)-4, IL-5, IL-13, and interferon-gamma (IFN-gamma) in bronchoalveolar lavage fluid (BALF) were measured by enzyme-linked immunosorbent assay (ELISA). Hematoxylin & eosin (H&E) and Periodic acid-Schiff (PAS) staining was performed on lung tissues. In addition, immunohistochemical staining for IL-4, IL-5, MUC5AC, and transforming growth factor alpha (TOE-alpha) was conducted. Results: Serum IgE levels were significantly higher in group 4 than in group 3 (P<0.05). IL-4 and IL-5 in BALF were significantly higher in group 4 than in group 3 (P<0.05, respectively). Based on H&E staining, inflammatory cell numbers were significantly greater in group 4 than in the other groups (P<0.05(. The number of PAS-positive cells was also significantly greater in groups 3 and 4 than in groups 1 and 2 (P<0.05). The numbers of IL-4 and IL-5-positive cells were higher in group 4 than in group 3 (P<0.05). The number of MUC5AC and TGF-alpha-positive cells were also higher in group 4 than in group 3 (P<0.05). Conclusions: Our data suggest that ASD increases cytokine expression and mucin production in an allergic murine model. The increased inflammatory reactions were related to cytokine production. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | - |
dc.relation.isPartOf | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | PARTICULATE MATTER | - |
dc.subject | MURINE LUNG | - |
dc.subject | KOREA | - |
dc.subject | PARTICLES | - |
dc.subject | AIRWAY | - |
dc.subject | SEOUL | - |
dc.subject | SECRETION | - |
dc.subject | MORTALITY | - |
dc.subject | TRANSPORT | - |
dc.title | Asian Sand Dust Enhances Allergen-Induced Th2 Allergic Inflammatory Changes and Mucin Production in BALB/c Mouse Lungs | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000305777400007 | - |
dc.identifier.doi | 10.4168/aair.2012.4.4.206 | - |
dc.identifier.bibliographicCitation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.4, no.4, pp.206 - 213 | - |
dc.identifier.kciid | ART001668508 | - |
dc.identifier.scopusid | 2-s2.0-84863880696 | - |
dc.citation.endPage | 213 | - |
dc.citation.startPage | 206 | - |
dc.citation.title | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.citation.volume | 4 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Kang, Il Gyu | - |
dc.contributor.affiliatedAuthor | Jung, Joo Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Seon Tae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Asian sand dust | - |
dc.subject.keywordAuthor | airway inflammation | - |
dc.subject.keywordAuthor | mucin | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | PARTICULATE MATTER | - |
dc.subject.keywordPlus | MURINE LUNG | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | AIRWAY | - |
dc.subject.keywordPlus | SEOUL | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
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