Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation
DC Field | Value | Language |
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dc.contributor.author | Park, Eonjeong | - |
dc.contributor.author | Yang, Yoon Jung | - |
dc.contributor.author | Kim, Aejin | - |
dc.contributor.author | Kwak, Jong Hwan | - |
dc.contributor.author | Jung, Young Hoon | - |
dc.contributor.author | Kang, Se Chan | - |
dc.contributor.author | Kim, In Su | - |
dc.date.available | 2020-02-29T05:47:12Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2012-06-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16334 | - |
dc.description.abstract | The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of beta-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | MAST-CELLS | - |
dc.subject | HINOKIRESINOL | - |
dc.subject | COMPOUND | - |
dc.subject | BIOLOGY | - |
dc.subject | KINASE | - |
dc.subject | PLANTS | - |
dc.subject | IGE | - |
dc.title | Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000303980600013 | - |
dc.identifier.doi | 10.1016/j.bmcl.2012.04.033 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.11, pp.3653 - 3655 | - |
dc.identifier.scopusid | 2-s2.0-84861193892 | - |
dc.citation.endPage | 3655 | - |
dc.citation.startPage | 3653 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 22 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Yang, Yoon Jung | - |
dc.contributor.affiliatedAuthor | Kang, Se Chan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Norlignan | - |
dc.subject.keywordAuthor | Degranulation | - |
dc.subject.keywordAuthor | Allergy | - |
dc.subject.keywordAuthor | IgE | - |
dc.subject.keywordAuthor | Derivative | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | HINOKIRESINOL | - |
dc.subject.keywordPlus | COMPOUND | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PLANTS | - |
dc.subject.keywordPlus | IGE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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