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Cited 3 time in webofscience Cited 5 time in scopus
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Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation

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dc.contributor.authorPark, Eonjeong-
dc.contributor.authorYang, Yoon Jung-
dc.contributor.authorKim, Aejin-
dc.contributor.authorKwak, Jong Hwan-
dc.contributor.authorJung, Young Hoon-
dc.contributor.authorKang, Se Chan-
dc.contributor.authorKim, In Su-
dc.date.available2020-02-29T05:47:12Z-
dc.date.created2020-02-06-
dc.date.issued2012-06-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16334-
dc.description.abstractThe synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of beta-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.-
dc.language영어-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.subjectMAST-CELLS-
dc.subjectHINOKIRESINOL-
dc.subjectCOMPOUND-
dc.subjectBIOLOGY-
dc.subjectKINASE-
dc.subjectPLANTS-
dc.subjectIGE-
dc.titleSynthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000303980600013-
dc.identifier.doi10.1016/j.bmcl.2012.04.033-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.11, pp.3653 - 3655-
dc.identifier.scopusid2-s2.0-84861193892-
dc.citation.endPage3655-
dc.citation.startPage3653-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume22-
dc.citation.number11-
dc.contributor.affiliatedAuthorYang, Yoon Jung-
dc.contributor.affiliatedAuthorKang, Se Chan-
dc.type.docTypeArticle-
dc.subject.keywordAuthorNorlignan-
dc.subject.keywordAuthorDegranulation-
dc.subject.keywordAuthorAllergy-
dc.subject.keywordAuthorIgE-
dc.subject.keywordAuthorDerivative-
dc.subject.keywordPlusMAST-CELLS-
dc.subject.keywordPlusHINOKIRESINOL-
dc.subject.keywordPlusCOMPOUND-
dc.subject.keywordPlusBIOLOGY-
dc.subject.keywordPlusKINASE-
dc.subject.keywordPlusPLANTS-
dc.subject.keywordPlusIGE-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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