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Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation
- Authors
- Park, Eonjeong; Yang, Yoon Jung; Kim, Aejin; Kwak, Jong Hwan; Jung, Young Hoon; Kang, Se Chan; Kim, In Su
- Issue Date
- 1-Jun-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Norlignan; Degranulation; Allergy; IgE; Derivative
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.11, pp.3653 - 3655
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 22
- Number
- 11
- Start Page
- 3653
- End Page
- 3655
- ISSN
- 0960-894X
- Abstract
- The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of beta-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC50 values of 18.3 and 17.9 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.
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