Effects of Korean Red Ginseng on Cognitive and Motor Function: A Double-blind, Randomized, Placebo-controlled Trial
- Authors
- Yeo, Hye-Bin; Yoon, Ho-Kyoung; Lee, Heon-Jeong; Kang, Seung-Gul; Jung, Ki-Young; Kim, Leen
- Issue Date
- Apr-2012
- Publisher
- KOREAN SOC GINSENG
- Keywords
- Panax ginseng; Cognitive and motor function; Evoked potentials; Korean red ginseng; Vienna test system
- Citation
- JOURNAL OF GINSENG RESEARCH, v.36, no.2, pp.190 - 197
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 36
- Number
- 2
- Start Page
- 190
- End Page
- 197
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16463
- DOI
- 10.5142/jgr.2012.36.2.190
- ISSN
- 1226-8453
- Abstract
- Ginseng has a long history of use for health enhancement, and there is some evidence from animal studies that it has a beneficial effect on cognitive performance. The purpose of this study was to investigate the effect of Korean red ginseng on cognitive performance in humans. A total of 15 healthy young males with no psychiatric or cognitive problems were selected based on an interview with a board-certified psychiatrist. The subjects were randomly assigned to receive a daily dose of 4,500 mg red ginseng or placebo for a 2-week trial. There were 8 subjects in the red ginseng group and 7 subjects in the placebo group. All of the subjects were analyzed with the Vienna test system and a P300 event-related potential (ERP) test. There were no significant differences in the Vienna test system scores between the red ginseng group and the placebo group. In the event-related potential test, the C3 latency of the red ginseng group tended to decrease during the study period (p=0.005). After 2 wk, significant decreases were observed in the P300 latencies at Cz (p=0.008), C3 (p=0.005), C4 (p=0.002), and C mean (p=0.003) in the red ginseng group. Our results suggest that the decreased latency in ERP is associated with improved cognitive function. Further studies with a higher dosage of ginseng, a larger sample size, and a longer follow-up period are necessary to confirm the clinical efficacy of Korean red ginseng.
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