Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, So-Yeon | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Choi, Jung-Hwan | - |
dc.date.available | 2020-02-29T06:44:39Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 1071-5762 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16536 | - |
dc.description.abstract | Peroxiredoxins (Prdx), a family of antioxidant proteins, have important defensive roles in the degenerative brain diseases and neuronal cell death in adult subjects. However, little is known in the neonatal brain. Here, we studied the developmental expression of Prdxs and their response to dexamethasone in the perinatal rat brain. Prdx 1 expression increased during late gestations and peaked at postnatal-day 1, when its expression gradually decreased. Prdx 2 expression remained largely unchanged. Prdx 6 expression continually increased as growing. Using immunohistochemistry, each Prdx showed a strong expression in the cerebral cortex and hippocampus. Prdx 1 was strongly expressed in the corpus callosum. The dexamethasone injection increased the expression of Prdx 6. In conclusion, we reveal for the first time that Prdx 1, 2 and 6 are found in abundance in the perinatal rat brain and are differentially expressed during development. The expression of Prdx 6 was affected by dexamethasone treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | INFORMA HEALTHCARE | - |
dc.relation.isPartOf | FREE RADICAL RESEARCH | - |
dc.subject | LUNG EPITHELIAL-CELLS | - |
dc.subject | 1-CYS PEROXIREDOXIN | - |
dc.subject | MAMMALIAN PEROXIREDOXIN | - |
dc.subject | THIOREDOXIN PEROXIDASE | - |
dc.subject | ANTIOXIDANT ENZYMES | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | REDUCE PEROXIDES | - |
dc.subject | APOPTOSIS | - |
dc.subject | ISOFORMS | - |
dc.subject | STRESS | - |
dc.title | Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000300444100001 | - |
dc.identifier.doi | 10.3109/10715762.2011.649749 | - |
dc.identifier.bibliographicCitation | FREE RADICAL RESEARCH, v.46, no.3, pp.231 - 239 | - |
dc.identifier.scopusid | 2-s2.0-84863116062 | - |
dc.citation.endPage | 239 | - |
dc.citation.startPage | 231 | - |
dc.citation.title | FREE RADICAL RESEARCH | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Shim, So-Yeon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | peroxiredoxin | - |
dc.subject.keywordAuthor | rat brain | - |
dc.subject.keywordAuthor | dexamethasone | - |
dc.subject.keywordAuthor | development | - |
dc.subject.keywordPlus | LUNG EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | 1-CYS PEROXIREDOXIN | - |
dc.subject.keywordPlus | MAMMALIAN PEROXIREDOXIN | - |
dc.subject.keywordPlus | THIOREDOXIN PEROXIDASE | - |
dc.subject.keywordPlus | ANTIOXIDANT ENZYMES | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | REDUCE PEROXIDES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ISOFORMS | - |
dc.subject.keywordPlus | STRESS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.