Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone
- Authors
- Shim, So-Yeon; Kim, Han-Suk; Kim, Ee-Kyung; Choi, Jung-Hwan
- Issue Date
- Mar-2012
- Publisher
- INFORMA HEALTHCARE
- Keywords
- antioxidant; peroxiredoxin; rat brain; dexamethasone; development
- Citation
- FREE RADICAL RESEARCH, v.46, no.3, pp.231 - 239
- Journal Title
- FREE RADICAL RESEARCH
- Volume
- 46
- Number
- 3
- Start Page
- 231
- End Page
- 239
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16536
- DOI
- 10.3109/10715762.2011.649749
- ISSN
- 1071-5762
- Abstract
- Peroxiredoxins (Prdx), a family of antioxidant proteins, have important defensive roles in the degenerative brain diseases and neuronal cell death in adult subjects. However, little is known in the neonatal brain. Here, we studied the developmental expression of Prdxs and their response to dexamethasone in the perinatal rat brain. Prdx 1 expression increased during late gestations and peaked at postnatal-day 1, when its expression gradually decreased. Prdx 2 expression remained largely unchanged. Prdx 6 expression continually increased as growing. Using immunohistochemistry, each Prdx showed a strong expression in the cerebral cortex and hippocampus. Prdx 1 was strongly expressed in the corpus callosum. The dexamethasone injection increased the expression of Prdx 6. In conclusion, we reveal for the first time that Prdx 1, 2 and 6 are found in abundance in the perinatal rat brain and are differentially expressed during development. The expression of Prdx 6 was affected by dexamethasone treatment.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16536)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.