Chemical Constituents from the Aerial Parts of Aster koraiensis with Protein Glycation and Aldose Reductase Inhibitory Activities
- Authors
- Lee, Jun; Lee, Yun Mi; Lee, Byong Won; Kim, Joo-Hwan; Kim, Jin Sook
- Issue Date
- Feb-2012
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.75, no.2, pp.267 - 270
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 75
- Number
- 2
- Start Page
- 267
- End Page
- 270
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16610
- DOI
- 10.1021/np200646e
- ISSN
- 0163-3864
- Abstract
- Two new eudesmane-type sesquiterpene glucosides, 9 beta-O-(E-p-hydroxycinnamoyl)-1 beta,6 beta-dihydroxy-trans-eu-desm-3-en-6-O-beta-D-glucopyranoside (1) and 9 alpha-O-(E-p-hydroxycinnamoyl)-1 alpha,6 alpha-11-trihydroxy-trans-eudesm-3-en-6-O-beta-D- glucopyranoside (2), were isolated by the activity-guided fractionation of an EtOAc-soluble fraction from the aerial parts of Aster koraiensis. A new dihydrobenzofuran glucoside, (2R,3S)-6-acetyl-2-[1-O-beta-D-glucopyranosyl)-2-propenyl]-5-hydroxy-3-methoxy-2,3-dihydrobenzofuran (3), was also isolated, in addition to 15 known compounds. The structures of 1-3 were determined by spectroscopic data interpretation. All of the isolates were evaluated for in vitro inhibitory activity against the formation of advanced glycation end-products and rat lens aldose reductase.
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