8-Hydroxydeoxyguanosine: Not mer biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases
DC Field | Value | Language |
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dc.contributor.author | Ock, Chan-Young | - |
dc.contributor.author | Kim, Eun-Hee | - |
dc.contributor.author | Choi, Duck Joo | - |
dc.contributor.author | Lee, Ho Jae | - |
dc.contributor.author | Hahm, Ki-Baik | - |
dc.contributor.author | Chung, Myung Hee | - |
dc.date.available | 2020-02-29T06:46:43Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-01-28 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16620 | - |
dc.description.abstract | Reactive oxygen species (ROS) attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine (8-OHdG), which can bind to thymidine rather than cytosine, based on which, the level of 8-OHdG is generally regarded as a biomarker of mutagenesis consequent to oxidative stress. For example, higher levels of 8-OHdG are noted in Helkobacter pylori-associated chronic atrophic gastritis as well as gastric cancer. However, we have found that exogenous 8-OHdG can paradoxically reduce ROS production, attenuate the nuclear factor-kappa B signaling pathway, and ameliorate the expression of proinflammatory mediators such as interleukin (IL)-1, IL-6, cyclo-mgenase-2, and inducible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-1, NOX organizer-1 and NOX activator-1 in various conditions of inflammation-based gastrointestinal (GI) diseases including gastritis, inflammatory bowel disease, pancreatitis, and even colitis-associated carcinogenesis. Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases, as well as the prevention of inflammation-associated GI cancer. In this editorial review, the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced. (C) 2012 Baishideng. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.subject | DNA-DAMAGE REPAIR | - |
dc.subject | HELICOBACTER-PYLORI | - |
dc.subject | CANCER PATIENTS | - |
dc.subject | NADPH OXIDASES | - |
dc.subject | CELL-LINE | - |
dc.subject | OGG1 | - |
dc.subject | RAC | - |
dc.subject | 8-HYDROXY-2&apos | - |
dc.subject | -DEOXYGUANOSINE | - |
dc.subject | 8-OXOGUANINE | - |
dc.subject | BINDING | - |
dc.title | 8-Hydroxydeoxyguanosine: Not mer biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000299965100002 | - |
dc.identifier.doi | 10.3748/wjg.v18.i4.302 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.18, no.4, pp.302 - 308 | - |
dc.identifier.scopusid | 2-s2.0-84862915473 | - |
dc.citation.endPage | 308 | - |
dc.citation.startPage | 302 | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Ock, Chan-Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Hee | - |
dc.contributor.affiliatedAuthor | Choi, Duck Joo | - |
dc.contributor.affiliatedAuthor | Lee, Ho Jae | - |
dc.contributor.affiliatedAuthor | Hahm, Ki-Baik | - |
dc.type.docType | Editorial Material | - |
dc.subject.keywordAuthor | 8-hydroxydeoxyguanosine | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Carcinogenesis | - |
dc.subject.keywordAuthor | Prevention | - |
dc.subject.keywordPlus | DNA-DAMAGE REPAIR | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | CANCER PATIENTS | - |
dc.subject.keywordPlus | NADPH OXIDASES | - |
dc.subject.keywordPlus | CELL-LINE | - |
dc.subject.keywordPlus | OGG1 | - |
dc.subject.keywordPlus | RAC | - |
dc.subject.keywordPlus | 8-HYDROXY-2&apos | - |
dc.subject.keywordPlus | -DEOXYGUANOSINE | - |
dc.subject.keywordPlus | 8-OXOGUANINE | - |
dc.subject.keywordPlus | BINDING | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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