8-Hydroxydeoxyguanosine: Not mer biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases
- Authors
- Ock, Chan-Young; Kim, Eun-Hee; Choi, Duck Joo; Lee, Ho Jae; Hahm, Ki-Baik; Chung, Myung Hee
- Issue Date
- 28-Jan-2012
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Keywords
- 8-hydroxydeoxyguanosine; Oxidative stress; Inflammation; Carcinogenesis; Prevention
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.18, no.4, pp.302 - 308
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 18
- Number
- 4
- Start Page
- 302
- End Page
- 308
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16620
- DOI
- 10.3748/wjg.v18.i4.302
- ISSN
- 1007-9327
- Abstract
- Reactive oxygen species (ROS) attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine (8-OHdG), which can bind to thymidine rather than cytosine, based on which, the level of 8-OHdG is generally regarded as a biomarker of mutagenesis consequent to oxidative stress. For example, higher levels of 8-OHdG are noted in Helkobacter pylori-associated chronic atrophic gastritis as well as gastric cancer. However, we have found that exogenous 8-OHdG can paradoxically reduce ROS production, attenuate the nuclear factor-kappa B signaling pathway, and ameliorate the expression of proinflammatory mediators such as interleukin (IL)-1, IL-6, cyclo-mgenase-2, and inducible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-1, NOX organizer-1 and NOX activator-1 in various conditions of inflammation-based gastrointestinal (GI) diseases including gastritis, inflammatory bowel disease, pancreatitis, and even colitis-associated carcinogenesis. Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases, as well as the prevention of inflammation-associated GI cancer. In this editorial review, the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative-stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced. (C) 2012 Baishideng. All rights reserved.
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