Which metabolic syndrome criteria best predict the presence of non-alcoholic fatty liver disease?
- Authors
- Il Seo, Hyun; Cho, Yong Kyun; Lee, Won Young; Rhee, Eun Jung; Sung, Ki Chul; Kim, Bum Soo; Son, Byung Ho; Shin, Jun Ho; Joo, Kwan Joong; Hong, Hyun Pyo; Chae, Seoung Wan; Jin, Wook
- Issue Date
- Jan-2012
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- NAFLD; Metabolic syndrome; Metabolic syndrome criteria
- Citation
- DIABETES RESEARCH AND CLINICAL PRACTICE, v.95, no.1, pp.19 - 24
- Journal Title
- DIABETES RESEARCH AND CLINICAL PRACTICE
- Volume
- 95
- Number
- 1
- Start Page
- 19
- End Page
- 24
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16650
- DOI
- 10.1016/j.diabres.2011.08.013
- ISSN
- 0168-8227
- Abstract
- Aims: To know which MS criteria best predict the presence of NAFLD and the prevalences of metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) diagnosed ultrasonographically among pre-diabetic and diabetic subjects based on three different MS criteria (IDF, ATP III, WHO). Methods: Subjects were screened and those with a fasting serum glucose level >= 100 mg/dL were further tested with a 75 g oral glucose tolerance test. And those who were newly diagnosed as having pre-diabetes or diabetes were evaluated for MS and NAFLD. We compared the risk ratios of NAFLD among three MS criteria using multivariate and multiple logistic regression analyses. Results: A total of 1365 subjects (977 males, mean age 48.4 +/- 9.5 years) were analyzed. The WHO criteria produced the highest prevalence of MS in both the pre-diabetic (49.8%) and diabetic (58.9%) groups. The IDF criteria produced the highest odds ratio for NAFLD in both pre-diabetic (3.89 [95% CI 2.75-5.51]) and diabetic (5.53 [95% CI 3.21-9.52]) groups. Conclusions: The prevalence of MS depends on the set of diagnostic criteria used. IDF criteria best predicts the presence of NAFLD. The presence of NAFLD should be considered as a component of the diagnostic criteria for MS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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