A CMOS image sensor to recognize the cardiovascular disease markers troponin I and C-reactive protein
- Authors
- Devadhasan, Jasmine Pramila; Marimuthu, Mohana; Kim, Sanghyo; Kim, Min-Gon
- Issue Date
- Jan-2012
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Complementary metal oxide semiconductor sensor; Indium nanoparticle; Troponin I protein; C-reactive protein
- Citation
- ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v.402, no.2, pp.813 - 821
- Journal Title
- ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Volume
- 402
- Number
- 2
- Start Page
- 813
- End Page
- 821
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16654
- DOI
- 10.1007/s00216-011-5478-1
- ISSN
- 1618-2642
- Abstract
- A complementary metal oxide semiconductor (CMOS) image sensor was utilized to detect the interaction of cardiovascular disease markers, troponin I and C-reactive protein. Each marker with its respective antibodies was adsorbed to an indium nanoparticle (InNP)-coated glass substrate. Dielectric layers of antigens and antibodies bound onto and interacted on conducting InNPs. Normal room light passed through these protein-layer-bound substrates and hit the CMOS image sensor surface, and the number of photons was detected and converted into digital form. We tested this approach for real-time monitoring of cardiac disease markers based on photon count, demonstrating its low cost and its capacity to detect antigens with high sensitivity at picogram per milliliter concentration.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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