Experimental murine fascioliasis derives early immune suppression with increased levels of TGF-β and IL-4
- Authors
- Chung, J.-Y.; Bae, Y.-A.; Yun, D.-H.; Yang, H.-J.; Kong, Y.
- Issue Date
- Dec-2012
- Publisher
- Korean Journal of Parasitology
- Keywords
- Fasciola hepatica; IL-4; Murine fascioliasis; T-lymphocyte; TGF-β
- Citation
- Korean Journal of Parasitology, v.50, no.4, pp.301 - 308
- Journal Title
- Korean Journal of Parasitology
- Volume
- 50
- Number
- 4
- Start Page
- 301
- End Page
- 308
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/16672
- DOI
- 10.3347/kjp.2012.50.4.301
- ISSN
- 0023-4001
- Abstract
- In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 postinfection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes signifcantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection. © 2012, Korean Society for Parasitology and Tropical Medicine.
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