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Electrical impedance detection of senescence in adipose tissue-derived stem cells

Authors
Jun, Hee-SookDao, Lan Thi MaiCho, Sungbo
Issue Date
Nov-2012
Publisher
ELSEVIER SCIENCE BV
Keywords
Aging; Cell morphology; Impedance spectroscopy; ITO electrode; Stem cells
Citation
Procedia Engineering, v.47, pp.1025 - 1028
Journal Title
Procedia Engineering
Volume
47
Start Page
1025
End Page
1028
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17426
DOI
10.1016/j.proeng.2012.09.323
ISSN
1877-7058
Abstract
For stem cell-based tissue engineering or tissue therapy, control of the quality of isolated stem cells is required. In this study, we used the electrical impedance spectroscopy to characterize the effect of passage on the morphological change and the proliferative capacity of adipose tissue-derived stem cells (ADSCs) during cell growth on the transparent ITO electrodes. ADSCs adhered to the ITO electrode and proliferated during cell growth. The phase contrast image of ADSCs on the electrode showed that the cells at passage 9 had a small and spindle-shaped morphology while the cells at passage 31 were flattened and larger than younger cells. The real part of the impedances of passage 9 cells were lower than passage 31 at the beginning time of culture due to the larger size of older cells adhered to the electrode. Then, the values of passage 9 cells were increased and distinguishable from passage 31 due the higher proliferation rate of younger cells. The experimental results showed that the impedance measurement could characterize the age-related morphological change and the proliferative capacity of ADSCs during cell growth. © 2012 The Authors. Published by Elsevier Ltd.
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Cho, Sungbo
반도체대학 (반도체·전자공학부)
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