Nuclear Barrier Hypothesis of Aging as Mechanism for Trade-Off Growth to Survival
DC Field | Value | Language |
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dc.contributor.author | Park, Sang Chul | - |
dc.date.available | 2020-02-29T09:46:23Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17537 | - |
dc.description.abstract | When the aging-dependent cellular behaviors toward growth factors and toxic stress have been analyzed, the perinuclear accumulation of the activated signals, either mitogenic or apoptotic, has been observed, suggesting the aging-dependent inefficiency of the nucleocytoplasmic trafficking of the signals. Thereby, it would be natural to assume the operation of the functional nuclear barrier in aging-dependent manner, which would be designated as "Park and Lim's Barrier." And for the ultimate transcriptional factor for these aging-dependent changes of the functional nuclear barrier, Sp1 transcriptional factor has been suggested to be the most probable candidate. This novel mechanism of aging-dependent operation of the functional nuclear barrier is proposed as the ultimate checking mechanism for cellular protection against toxic environment and the general mechanism for the trade-off growth to survival in aging. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER INTERNATIONAL PUBLISHING AG | - |
dc.relation.isPartOf | HUMAN CELL TRANSFORMATION: ROLE OF STEM CELLS AND THE MICROENVIRONMENT | - |
dc.title | Nuclear Barrier Hypothesis of Aging as Mechanism for Trade-Off Growth to Survival | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000339175100002 | - |
dc.identifier.doi | 10.1007/978-1-4614-0254-1_1 | - |
dc.identifier.bibliographicCitation | HUMAN CELL TRANSFORMATION: ROLE OF STEM CELLS AND THE MICROENVIRONMENT, v.720, pp.3 - 13 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-80053898525 | - |
dc.citation.endPage | 13 | - |
dc.citation.startPage | 3 | - |
dc.citation.title | HUMAN CELL TRANSFORMATION: ROLE OF STEM CELLS AND THE MICROENVIRONMENT | - |
dc.citation.volume | 720 | - |
dc.contributor.affiliatedAuthor | Park, Sang Chul | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.subject.keywordPlus | HUMAN-DIPLOID FIBROBLASTS | - |
dc.subject.keywordPlus | CAVEOLIN-SCAFFOLDING DOMAIN | - |
dc.subject.keywordPlus | SENESCENT HUMAN-FIBROBLASTS | - |
dc.subject.keywordPlus | RECEPTOR-MEDIATED ENDOCYTOSIS | - |
dc.subject.keywordPlus | PROSTATE-CANCER CELLS | - |
dc.subject.keywordPlus | PROTEIN-KINASES | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LYSOPHOSPHATIDIC ACID | - |
dc.subject.keywordPlus | APOPTOSIS RESISTANCE | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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