Nuclear Barrier Hypothesis of Aging as Mechanism for Trade-Off Growth to Survival
- Authors
- Park, Sang Chul
- Issue Date
- Jan-2012
- Publisher
- SPRINGER INTERNATIONAL PUBLISHING AG
- Citation
- HUMAN CELL TRANSFORMATION: ROLE OF STEM CELLS AND THE MICROENVIRONMENT, v.720, pp.3 - 13
- Journal Title
- HUMAN CELL TRANSFORMATION: ROLE OF STEM CELLS AND THE MICROENVIRONMENT
- Volume
- 720
- Start Page
- 3
- End Page
- 13
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17537
- DOI
- 10.1007/978-1-4614-0254-1_1
- ISSN
- 0065-2598
- Abstract
- When the aging-dependent cellular behaviors toward growth factors and toxic stress have been analyzed, the perinuclear accumulation of the activated signals, either mitogenic or apoptotic, has been observed, suggesting the aging-dependent inefficiency of the nucleocytoplasmic trafficking of the signals. Thereby, it would be natural to assume the operation of the functional nuclear barrier in aging-dependent manner, which would be designated as "Park and Lim's Barrier." And for the ultimate transcriptional factor for these aging-dependent changes of the functional nuclear barrier, Sp1 transcriptional factor has been suggested to be the most probable candidate. This novel mechanism of aging-dependent operation of the functional nuclear barrier is proposed as the ultimate checking mechanism for cellular protection against toxic environment and the general mechanism for the trade-off growth to survival in aging.
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