Crush Cytologic Findings of a Cerebral Granular Cell Astrocytoma
- Authors
- Kang, Myunghee; Kim, Na Rae; Chung, Dong Hae; Yoo, Chan Jong
- Issue Date
- Sep-2012
- Publisher
- KARGER
- Keywords
- Granular cell astrocytoma; Crush cytology; Immunohistochemistry
- Citation
- ACTA CYTOLOGICA, v.56, no.5, pp.571 - 575
- Journal Title
- ACTA CYTOLOGICA
- Volume
- 56
- Number
- 5
- Start Page
- 571
- End Page
- 575
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17580
- DOI
- 10.1159/000338392
- ISSN
- 0001-5547
- Abstract
- Background: Granular cell astrocytoma (GCA) is a rare variant of astrocytoma, characterized by an aggressive prognosis compared to conventional astrocytomas of the same World Health Organization grade. Intraoperative smears provide useful clues in diagnosing neuropathology, especially in rarely encountered central nervous system tumors. Case: The patient was a 53-year-old man who presented with a huge mass at the left temporal lobe with peritumoral edema on MRI. The crush smears revealed singly-scattered, large eosinophilic cells with eccentrically located nuclei as well as plump, finely-granular cytoplasm with distinct borders. Mild cellular atypia and absence of mitotic activity were noted. These cells were admixed with small mature lymphoid cells. Histology showed scattered large granular cells which were positive for glial fibrillary acidic protein. Conclusion: The most helpful imprint cytologic findings of GCA were as follows: (1) large cells containing eosinophilic granular cytoplasm rather than the foamy or bubbly cytoplasm associated with macrophages or renal cell carcinomas; (2) distinct granular cell borders in contrast to the ruffled membrane of macrophages, and (3) markedly large-sized granular cells, ranging from 60 to 100 mu m in diameter. Copyright (c) 2012 S. Karger AG, Basel
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
- 의과대학 > 의예과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.