Reducing Radiation Dermatitis Using a Film-forming Silicone Gel During Breast Radiotherapy: A Pilot Randomized-controlled Trial
- Authors
- Ahn, Songmi; Sung, Kihoon; Kim, Hyun Ju; Choi, Young Eun; Lee, Young Kyu; Kim, Jeong Soo; Lee, Seul Ki; Roh, Joo-Young
- Issue Date
- Jan-2020
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Film-forming silicone gel; StrataXRT; radiation dermatitis; breast cancer
- Citation
- IN VIVO, v.34, no.1, pp.413 - 422
- Journal Title
- IN VIVO
- Volume
- 34
- Number
- 1
- Start Page
- 413
- End Page
- 422
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17653
- DOI
- 10.21873/invivo.11790
- ISSN
- 0258-851X
- Abstract
- Background/Aim: To evaluate whether topical use of a film forming silicone gel (StrataXRT (R)) could reduce radiation dermatitis compared to a moisturizing cream (X-derm (R)) in patients receiving whole breast radiotherapy. Patients and Methods: A total of 56 patients with breast cancer were randomized to use StrataXRT or X-derm. The severity of radiation dermatitis was graded using physiological skin parameters, clinician-assessed visual rating scales and patient-reported symptoms. Changes in these parameters from baseline to 4 weeks post-radiotherapy were evaluated every two weeks. Results: Two-way repeated-measures ANOVA revealed different patterns of changes in the erythema index (F=3.609, p=0.008) and melanin index (F=3.475, p=0.015). The post hoc analysis demonstrated a significantly lower erythema index and melanin index in the patients allocated to the StrataXRT group. Conclusion: The use of StrataXRT can reduce radiation dermatitis with respect to objectively measured physiological skin parameters. The results of the present study will support the feasibility of conducting a larger randomized controlled trial.
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