Bioactive secondary metabolites from an endophytic fungus Phoma sp. PF2 derived from Artemisia princeps Pamp
- Authors
- Kim, Jung Wha; Choi, Hyun Gyu; Song, Ji Hoon; Kang, Ki Sung; Shim, Sang Hee
- Issue Date
- Mar-2019
- Publisher
- JAPAN ANTIBIOTICS RESEARCH ASSOC
- Citation
- JOURNAL OF ANTIBIOTICS, v.72, no.3, pp.174 - 177
- Journal Title
- JOURNAL OF ANTIBIOTICS
- Volume
- 72
- Number
- 3
- Start Page
- 174
- End Page
- 177
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1767
- DOI
- 10.1038/s41429-018-0131-2
- ISSN
- 0021-8820
- Abstract
- Two new isochromanone derivatives, (3S,4S)-3,8-dihydroxy-6-methoxy-3,4,5-trimethylisochroman-1-one (1) and methyl (S)-8-hydroxy-6-methoxy-5-methyl-4a-(3-oxobutan-2-yl)benzoate (2), together with six known compounds (3-8) were isolated from the cultures of an endophytic fungus Phoma sp. PF2 obtained from Artemisia princeps. The chemical structures of the isolated compounds were elucidated by interpretation of spectroscopic data (1D, 2D NMR, HRESIMS, and CD) and calculation of ECD. All the isolated compounds (1-8) showed moderate inhibitory activities on nitric oxide levels in lipopolysaccharide-induced RAW264.7 machrophage cells.
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