Development and clinical study of the use of infrared radiation to accelerate the dissolution rate of a microneedle array patch (MAP)
- Authors
- Park, Jee-Hyun; Kim, Cheong Bi; Lee, Hyun-Ji; Roh, Joo Young; Lee, Jae Myun; Kim, Hee Joo; Park, Jung-Hwan
- Issue Date
- Jun-2020
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Active evaporating; Clinical study; Dissolution rate; Dissolving microneedle array patch (MAP); Erythema; Infrared radiation; Transepidermal water loss (TEWL)
- Citation
- Drug Delivery and Translational Research, v.10, no.3, pp.791 - 800
- Journal Title
- Drug Delivery and Translational Research
- Volume
- 10
- Number
- 3
- Start Page
- 791
- End Page
- 800
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17738
- DOI
- 10.1007/s13346-020-00710-x
- ISSN
- 2190-393X
- Abstract
- The dissolution rate of a microneedle array patch (MAP) determines how long a MAP must remain attached to the skin (often called “wear time”). In this study, the dissolution rate of a MAP was increased, not by changing the drug formulation but by employing an infrared (IR) device that is widely used for hospital treatment and in-home therapy. A MAP with microneedles 480 μm in height was prepared using hyaluronic acid (HA). Changes in transepidermal water loss (TEWL), the surface temperature of the skin, and the dissolution rate of the MAP tips with IR irradiation were evaluated on human skin in vivo. Time for recovery from erythema that occurred after MAP attachment and IR irradiation was also evaluated. TEWL increased more than fourfold with IR irradiation. Water that evaporated as a result of IR irradiation was trapped in the skin layer by the patch, resulting in the increased dissolution rate of the MAP tips. After 10 min of IR irradiation, the height of the dissolving tips compared with their initial height increased from 41 to 56%, and the dissolved volume of the tips compared with their initial volume increased from 7 to 18%. During the 10 min of irradiation, the skin surface temperature rose from 32 to 40 °C. Erythema occurred in the early stage of treatment with IR irradiation and MAP attachment, but it abated within 2 h after removal of the MAP and cessation of IR irradiation. Through this study, it was possible to shorten the administration time of MAPs by using an IR device that could be easily accessed. This method can be applied to various types of MAPs in order to reduce the time that the MAPs must remain attached to the skin without changing the drug formulation. [Figure not available: see fulltext.]. © 2020, Controlled Release Society.
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