Effects of resveratrol on bone-healing capacity in the mouse tooth extraction socket
- Authors
- Min, Kyung-Kon; Neupane, Sanjiv; Adhikari, Nirpesh; Sohn, Wern-Joo; An, Seo-Young; Kim, Ji-Youn; An, Chang-Hyeon; Lee, Youngkyun; Kim, Yong-Gun; Park, Jin-Woo; Lee, Jae-Mok; Kim, Jae-Young; Suh, Jo-Young
- Issue Date
- Apr-2020
- Publisher
- WILEY
- Keywords
- bone formation; drug efficacy; resveratrol; tooth extraction
- Citation
- JOURNAL OF PERIODONTAL RESEARCH, v.55, no.2, pp.247 - 257
- Journal Title
- JOURNAL OF PERIODONTAL RESEARCH
- Volume
- 55
- Number
- 2
- Start Page
- 247
- End Page
- 257
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17846
- DOI
- 10.1111/jre.12710
- ISSN
- 0022-3484
- Abstract
- Background and Objective After tooth extraction, the extraction socket undergoes several steps of soft and hard tissue healing. The healing process of the extraction socket is modulated by a range of signaling factors and biochemical agents. It has been reported that resveratrol, a polyphenolic compound, exhibits various biological effects, including anti-inflammatory, anti-carcinogenic, antioxidant, and anti-aging effects, and protects cardiovascular and bone tissues. In this study, we examined the cellular effects of resveratrol on human periodontal ligament (hPDL) cells and osteoblast-like (MC3T3-E1) cells and evaluated the bone-healing capacity of tooth extraction sockets in mice. Material and Methods Resveratrol was applied to hPDL and MC3T3-E1 cells to detect cell proliferation and alkaline phosphatase (ALP) activity, and qPCR was employed to understand the gene expression level in vitro. For in vivo experiment, six-week-old C57BL/6 male mice were randomly divided into control (n = 15) and experimental (n = 15) groups and maxillary first molars were extracted by surgery. Experimental groups received 50-mu M resveratrol on extraction sockets and analyzed the degree of new bone formation. Results Treatment of hPDL and MC3T3-E1 cells with resveratrol increased the cell proliferation and ALP activity and enhanced the expression of ALP, BMP-2, BMP-4, and OC genes. Resveratrol enhanced new bone formation in the lingual extraction socket in mice. Conclusion These results suggest that resveratrol increases the cellular physiology of PDL and osteoblast including their proliferation and differentiation and may play an important role in bone-healing capacity after tooth extraction.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 보건과학대학 > 치위생학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17846)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.