Detailed Information

Cited 15 time in webofscience Cited 17 time in scopus
Metadata Downloads

Effects of Lespedeza Bicolor Extract on Regulation of AMPK Associated Hepatic Lipid Metabolism in Type 2 Diabetic Mice

Authors
Kim, YounmiLee, HeajiKim, Sun YeouLim, Yunsook
Issue Date
Dec-2019
Publisher
MDPI
Keywords
Lespedeza bicolor; type 2 diabetes; AMPK; lipid metabolism; inflammation; oxidative stress; fibrosis
Citation
ANTIOXIDANTS, v.8, no.12
Journal Title
ANTIOXIDANTS
Volume
8
Number
12
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17931
DOI
10.3390/antiox8120599
ISSN
2076-3921
Abstract
Lespedeza bicolor (LB) is one of the ornamental plants used for the treatment of inflammation caused by oxidative damage. However, its beneficial effects on hyperglycemia-induced hepatic damage and the related molecular mechanisms remain unclear. We hypothesized that Lespedeza bicolor extract (LBE) would attenuate hyperglycemia-induced liver injury in type 2 diabetes mellitus (T2DM). Diabetes was induced by a low dosage of streptozotocin (STZ) injection (30 mg/kg) with a high fat diet in male C57BL/6J mice. LBE was administered orally at 100 mg/kg or 250 mg/kg for 12 weeks. LBE supplementation regardless of dosage ameliorated plasma levels of hemoglobin A1c (HbA1c) in diabetic mice. Moreover, both LBE supplementations upregulated AMP-activation kinase (AMPK), which may activate sirtuin1 (SIRT) associated pathway accompanied by decreased lipid synthesis at low dose of LBE supplementation. These changes were in part explained by reduced protein levels of oxidative stress (nuclear factor erythroid 2-related factor 2 (Nrf2) and catalase), inflammation (nuclear factor kappa B (NF-kappa B), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and nitric oxide synthases (iNOS)), and fibrosis (alpha-smooth muscle actin (alpha-SMA) and protein kinase C (PKC)) in diabetic liver. Taken together, LBE might be a potential nutraceutical to ameliorate hepatic damage by regulation of AMPK associated pathway via oxidative stress, inflammation, and fibrosis in T2DM.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Sun Yeou photo

Kim, Sun Yeou
Pharmacy (Dept.of Pharmacy)
Read more

Altmetrics

Total Views & Downloads

BROWSE