Cerium Aminoclay-A Potential Hybrid Biomaterial for Anticancer Therapy
- Authors
- Le Thi Nhu Ngoc; Park, Se-Myo; Oh, Jung-Hwa; Shin, Ho Yun; Kim, Moon Il; Lee, Hyun Uk; Lee, Kyung-Bok; Lee, Kug-Seung; Moon, Ju-Young; Kwon, Oh-Hyeok; Yang, Hee Young; Lee, Young-Chul
- Issue Date
- Nov-2019
- Publisher
- AMER CHEMICAL SOC
- Keywords
- Ce-aminoclay; in vitro cytotoxicity; in vivo antitumor; bioimaging; anticancer
- Citation
- ACS BIOMATERIALS SCIENCE & ENGINEERING, v.5, no.11, pp.5857 - 5871
- Journal Title
- ACS BIOMATERIALS SCIENCE & ENGINEERING
- Volume
- 5
- Number
- 11
- Start Page
- 5857
- End Page
- 5871
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17986
- DOI
- 10.1021/acsbiomaterials.9b00789
- ISSN
- 2373-9878
- Abstract
- In this study, novel biomedical properties of Ce-aminoclay (CeAC) were investigated through in vitro and in vivo assays. CeAC (>= 500 mu g/mL) can selectively kill cancer cells (A549, Huh-1, AGS, C33A, HCT116, and MCF-7 cells) while leaving most normal cells unharmed (WI-38 and CCD-18Co cells). Notably, it displayed a high contrast of simultaneous imaging in HeLa cells by blue photoluminescence without any fluorescence dye. Its anticancer mechanism has been fully demonstrated through apoptosis assays; herein CeAC induced high-level apoptosis (16%), which promoted the expression of proapoptotic proteins (Bax, p53, and caspase 9) in tumor cells. Besides, its biological behavior was determined through antitumor effects using intravenous and intratumoral administration routes in mice implanted with HCT116 cells. During a 40 day trial, the tumor volume and tumor weight were reduced by a maximum of 92.24 and 86.11%, respectively. The results indicate that CeAC exhibits high bioavailability and therapeutic potential based on its unique characteristics, including high antioxidant capacity and electrostatic interaction between its amino functional groups and the mucosal surface of cells. In summary, it is suggested that CeAC, with its high bioimaging contrast, can be a promising anticancer agent for future biomedical applications.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
- 산업·환경대학원 > 산업환경공학과 > 1. Journal Articles
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