In Vivo and In Vitro Study of Immunostimulation by Leuconostoc lactis-Produced Gluco-Oligosaccharides
DC Field | Value | Language |
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dc.contributor.author | Lee, Sulhee | - |
dc.contributor.author | Song, In Ho | - |
dc.contributor.author | Park, Young-Seo | - |
dc.date.available | 2020-03-03T07:44:36Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17993 | - |
dc.description.abstract | Glycosyltransferase-producing Leuconostoc lactis CCK940 produces CCK- oligosaccharides, gluco-oligosaccharide molecules, using sucrose and maltose as donor and acceptor molecules, respectively. In this study, the immunostimulatory activities of CCK-oligosaccharides on RAW264.7 macrophages and BALB/c mice were evaluated. CCK-oligosaccharides induced the expression of phosphorylated-p38, extracellular-signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) and upregulation of phagocytic activity in RAW264.7 macrophages, suggesting their involvement in mitogen-activated protein kinase (MAPK) signaling pathway and phagocytosis. When CCK-oligosaccharides were administered to mice intraperitoneally injected with cyclophosphamide (CY), spleen indices and expressions of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha increased, compared with those in only CY-treated group. These findings suggest that CCK-oligosaccharides can be used as an effective immunostimulating agent. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | POLYSACCHARIDE | - |
dc.subject | CELLS | - |
dc.subject | IMMUNOSUPPRESSION | - |
dc.subject | IL-10 | - |
dc.subject | CHITOOLIGOSACCHARIDES | - |
dc.subject | PHAGOCYTOSIS | - |
dc.subject | MACROPHAGES | - |
dc.subject | ACTIVATION | - |
dc.title | In Vivo and In Vitro Study of Immunostimulation by Leuconostoc lactis-Produced Gluco-Oligosaccharides | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000498055500183 | - |
dc.identifier.doi | 10.3390/molecules24213994 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.24, no.21 | - |
dc.identifier.scopusid | 2-s2.0-85074626536 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 24 | - |
dc.citation.number | 21 | - |
dc.contributor.affiliatedAuthor | Lee, Sulhee | - |
dc.contributor.affiliatedAuthor | Park, Young-Seo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | oligosaccharides | - |
dc.subject.keywordAuthor | immunostimulation | - |
dc.subject.keywordAuthor | MAPK signaling pathway | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.subject.keywordAuthor | cyclophosphamide | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | POLYSACCHARIDE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | IMMUNOSUPPRESSION | - |
dc.subject.keywordPlus | IL-10 | - |
dc.subject.keywordPlus | CHITOOLIGOSACCHARIDES | - |
dc.subject.keywordPlus | PHAGOCYTOSIS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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