Physiological application of nanoparticles in calcium-related proteins and channels
- Authors
- Lee, Dongun; Hong, Jeong Hee
- Issue Date
- Sep-2019
- Publisher
- FUTURE MEDICINE LTD
- Keywords
- Ca2+ ATPase; Ca2+ signaling; cytotoxicity; G protein-coupled receptors; nanoparticles; signal transduction; store-operated Ca2+ channels; transient receptor potential channels; voltage-gated Ca2+ channels
- Citation
- NANOMEDICINE, v.14, no.18, pp.2479 - 2486
- Journal Title
- NANOMEDICINE
- Volume
- 14
- Number
- 18
- Start Page
- 2479
- End Page
- 2486
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/18233
- DOI
- 10.2217/nnm-2019-0004
- ISSN
- 1743-5889
- Abstract
- Nanoparticles (NPs) have been studied as therapeutic drug-delivery agents for promising clinical trial outcomes. Nanomaterial-based drugs can transfer conventional drugs to target lesions, such as tumors, with increasing efficiency by enhancing drug-cell interaction or drug absorption. Although they are favorable as efficient drug transfer systems, NPs also exhibit cytotoxicity that affects nonpathological regions. Here, we review the basic information behind NP-induced Ca2+ signaling and its participation in channel physiology and pathology. NPs are observed to demonstrate inhibitory or active effects on Ca2+ signaling. Thus, understanding Ca2+ signaling by NPs as a key mechanism in signal transduction will progress the application of nano-drugs in various diseases without deleterious effect.
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