The Effects of Bee Venom Pharmacopuncture on Middle Cerebral Artery Occlusion Ischemic Cerebral Damage in Mice
- Authors
- 이지인; 송호섭
- Issue Date
- 2019
- Publisher
- 대한침구의학회
- Keywords
- bee venom; ischemia; middle cerebral artery occlusion; NF-kB; pharmacopuncture; stroke
- Citation
- Journal of Acupuncture Research, v.36, no.4, pp.220 - 229
- Journal Title
- Journal of Acupuncture Research
- Volume
- 36
- Number
- 4
- Start Page
- 220
- End Page
- 229
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/19445
- ISSN
- 2586-288X
- Abstract
- Background: The therapeutic potential of Bee Venom Pharmacopuncture (BVP) on acute ischemic cerebral infraction was determined in mice in vivo and in vitro.
Methods: Analysis of acute ischemic cerebral infraction was performed using 7 week old male ICR mice (n = 20) and microglial BV-2 cells. Bee venom (5 µg/kg) was injected into the caudal vein of middle cerebral artery occlusion (MCAo) mice (1 hour after reperfusion, 3 hours after MCAo probe insertion), and also used to treat LPS-stimulated microglial BV-2 cells (1, 2, 5 µg/mL). Markers of inflammation were monitored.
Results: NO declined statistically significantly in BVP treated MCAo mice compared to the untreated MCAo group (p < 0.05). Compared to the MCAo group, the BVP-treated MCAo group showed a decreased production volume of malondialdehyde, but an increased glutathione/oxidized glutathione ratio. Compared to the untreated MCAo group, the BVP treated MCAo group showed a statistically significant decline in TNF and IL-1β levels (p < 0.05). BVP inhibited the levels of p65, p50, p-IκB-α, and levels of p-ERK1/2, p-JNK2, p-P38 declined.
Conclusion: BVP is effective at dampening the inflammatory response in vivo and in vitro and may supplement rt-PA treatment.
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