Anti-varicella-zoster virus activity of cephalotaxine esters in vitro
- Authors
- Kim, Jung-Eun; Song, Yoon-Jae
- Issue Date
- Jan-2019
- Publisher
- MICROBIOLOGICAL SOCIETY KOREA
- Keywords
- varicella zoster virus; antiviral; harringtonine; homoharringtonine
- Citation
- JOURNAL OF MICROBIOLOGY, v.57, no.1, pp.74 - 79
- Journal Title
- JOURNAL OF MICROBIOLOGY
- Volume
- 57
- Number
- 1
- Start Page
- 74
- End Page
- 79
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2009
- DOI
- 10.1007/s12275-019-8514-z
- ISSN
- 1225-8873
- Abstract
- Harringtonine (HT) and homoharringtonine (HHT), alkaloid esters isolated from the genus Cephalotaxus, exhibit antitumor activity. A semisynthetic HHT has been approved for treatment of chronic myelogenous leukemia. In addition to antileukemic activity, HT and HHT are reported to possess potent antiviral activity. In this study, we investigated the effects of HT and HHT on replication of varicella-zoster virus (VZV) in vitro. HT and HHT, but not their biologically inactive parental alkaloid cephalotaxine (CET), significantly inhibited replication of recombinant VZV-pOka luciferase. Furthermore, HT and HHT, but not CET, strongly induced down-regulation of VZV lytic genes and exerted potent antiviral effects against a VZV clinical isolate. The collective data support the utility of HT and HHT as effective antiviral candidates for treatment of VZV-associated diseases.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2009)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.