Three New Lignan Glycosides from the Firmiana simplex
- Authors
- Woo, Kyeong Wan; Park, Jong Eel; Cha, Joon Min; Subedi, Lalita; Kim, Sun Yeou; Lee, Kang Ro
- Issue Date
- Jan-2019
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Firmiana simplex; Sterculiaceae; lignan glycoside; nitric oxide; neuroinflammatory effect
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.67, no.1, pp.18 - 22
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- Volume
- 67
- Number
- 1
- Start Page
- 18
- End Page
- 22
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2014
- DOI
- 10.1248/cpb.c18-00537
- ISSN
- 0009-2363
- Abstract
- In our quest for structurally intriguing compounds from Korean medicinal plant sources, chromatographic separation of the 80% MeOH extract from Firmiana simplex resulted in the isolation and identification of three new lignan glycosides (1-3), together with six known lignan glycosides (4-9). The structures of 1-3 were determined on the basis of spectroscopic analyses, including extensive 2D-NMR and enzyme hydrolysis. Nitric oxide (NO) production was evaluated in the lipopolysaccharide-activated microglial cell line, BV-2 to investigate the anti-neuroinflammatory effects of the isolated compounds (1-9). Compound 7 marginally inhibited NO levels with IC50 values of 59.83 mu M.
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