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Post-exposure prophylaxis for Middle East respiratory syndrome in healthcare workers
- Authors
- Park, S. Y.; Lee, J. S.; Son, J. S.; Ko, J. H.; Peck, K. R.; Jung, Y.; Woo, H. J.; Joo, Y. S.; Eom, J. S.; Shi, H.
- Issue Date
- Jan-2019
- Publisher
- W B SAUNDERS CO LTD
- Keywords
- Post-exposure prophylaxis; Middle East respiratory syndrome coronavirus; Outbreak; Healthcare worker; High-risk exposure; Pre-isolation pneumonia
- Citation
- JOURNAL OF HOSPITAL INFECTION, v.101, no.1, pp.42 - 46
- Journal Title
- JOURNAL OF HOSPITAL INFECTION
- Volume
- 101
- Number
- 1
- Start Page
- 42
- End Page
- 46
- ISSN
- 0195-6701
- Abstract
- An effective post-exposure prophylaxis (PEP) strategy may limit the spread of infection. However, there is no consensus regarding PEP for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. This study assessed the efficacy of ribavirin and lopinavir/ritonavir as PEP for healthcare workers (HCWs) exposed to patients with severe MERS-CoV pre-isolation pneumonia. The safety of the PEP regimen was assessed. HCWs with high-risk exposure to MERS-CoV pre-isolation pneumonia were retrospectively enrolled. HCWs who received PEP therapy were classified into the PEP group. PEP therapy was associated with a 40% decrease in the risk of infection. There were no severe adverse events during PEP therapy. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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Related Researcher
- Eom, Joong Sik
- College of Medicine (Department of Medicine)