Comparison of the Response Evaluation Criteria in Solid Tumors with Volumetric Measurement for Evaluation of Response and Overall Survival with Liver Metastases from Colorectal Cancer대장암 간전이 환자에서 반응평가와 생존율 예측 연구: 종양 부피 측정과 RECIST 기준의 비교
- Other Titles
- 대장암 간전이 환자에서 반응평가와 생존율 예측 연구: 종양 부피 측정과 RECIST 기준의 비교
- Authors
- 이인선; 최승준; 서초롱; 김준성
- Issue Date
- Sep-2019
- Publisher
- 대한영상의학회
- Keywords
- Colorectal Neoplasm; Neoplasm Metastasis; Chemotherapy; Outcomes Assessment
- Citation
- 대한영상의학회지, v.80, no.5, pp.906 - 918
- Journal Title
- 대한영상의학회지
- Volume
- 80
- Number
- 5
- Start Page
- 906
- End Page
- 918
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2255
- DOI
- 10.3348/jksr.2019.80.5.906
- ISSN
- 1738-2637
- Abstract
- Purpose The aim of this study was to compare the measurements of diameter and volume of hepatic metastases from CT images with the overall survival and tumor response, in patients with unresectable liver metastases of colorectal cancer treated with a targeted agent.
Materials and Methods We recruited 43 patients with unresectable liver metastases of colorectal cancer, in whom targeted therapy was used as the first-line treatment. Three-dimensional quantification of the volume of hepatic metastases was performed for each patient. An independent survival analysis using the Response Evaluation Criteria in Solid Tumors guidelines was performed and compared to the volumetric measurement. Overall survival was evaluated using the Kaplan-Meier analysis and compared to the Cox proportional hazard ratios (HRs) following univariate and multivariate analyses.
Results In patients classified as non-progressing and progressing by the volumetric criteria, the median overall survival time was 21 months [95% confidence interval (CI): 491.25–768.75] and 11 months (95% CI: 0–949.42), respectively (p = 0.001). Using a multivariate analysis, we found that volumetric response (HR: 3.467; p = 0.002) was a significant factor affecting the overall survival in patients with liver metastases of colorectal cancer.
Conclusion Volumetric assessment of liver metastases could be an alternative predictor of the overall survival of patients with liver metastases of colorectal cancer treated with a targeted agent.
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