OVA-유도 쥐 모델에서 기도 세포 침윤에 대한 KM1701의 억제효과Inhibitory Effects of KM1701 on Airway Cell Infiltration in OVA-Induced Mouse Model
- Other Titles
- Inhibitory Effects of KM1701 on Airway Cell Infiltration in OVA-Induced Mouse Model
- Authors
- 임순민; 최한석; 김상백; 김예진; 강기성; 신명숙; 김경준; 황귀서; 구본암
- Issue Date
- May-2019
- Publisher
- 대한한방안이비인후피부과학회
- Keywords
- KM1701; Airway Cell Infiltration; OVA-induced Mouse Model
- Citation
- 한방안이비인후피부과학회지, v.32, no.2, pp.1 - 10
- Journal Title
- 한방안이비인후피부과학회지
- Volume
- 32
- Number
- 2
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2496
- ISSN
- 1738-6640
- Abstract
- Objectives : The objective of present study is to evaluate anti-inflammatory and anti-allergic effects of Perilla(Perilla frutescens; Labiatae, PF), the roots of Peucedanum praeruptorum(PP) and the root of Scutellaria baicalensis(SB) in vitro and anti-asthmatic effects of mixture of PF, PP and SB(PS) on ovalbumin (OVA)-induced asthma in BALB/c mice.
Methods : Anti-inflammatory and anti-allergic effects were observed on the lipopolysaccharide(LPS) treated RAW 264.7 cells through Nitric Oxide(NO) production and RBL-2H3 cells through β-hexosaminidase. Anti-asthmatic effects were observed on the number of inflammatory cells in bronchoalveolar lavage fluid(BALF) and the level of IgE in serum on OVA-induced BALB/c mice.
Results : The treatment of PF, PP and SB(12.5, 25, 50, 100㎍/㎖) resulted in a significant inhibition of NO production in RAW 264.7 cells and mast cell degranulation in RBL-2H3 cells. Oral administration of PS(400㎎/㎏/day) resulted in a significant reduction in the numbers of eosinophils in BALF and level of IgE in serum.
Conclusion : The oral administration of PS is effective in ameliorating the eosinophilic infiltration in vivo and thus can be a good therapeutic candidate for allergic asthma.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의학과 > 1. Journal Articles
- 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2496)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.