인체에 약물운반을 위한 Glycine-Fe3O4-Chitosan 나노입자 전달체의 제조

Abstract

Recently, drug delivery system (DDS) which has been a major interesting area means the biomedical method that can maximize curative value and minimize side effect for the treatment of the sick by controlling drug releasing amount and velocity over time for the targeting drug to affected part. Chitosan from chitin has amine group having positive charge which can show great role of drug carrier. Chitosan nanoparticles which are biodegradable, biocompatible, and harmless to human body could be made nontoxic drug carrier. Glycine is the simplest possible amino acid that has only one hydrogen atom as an alkyl side group. It is one of the protein genic and achiral amino acid. Glycine is a crystalline powder and an important neurotransmitter in the central neuron system, particularly brain, spinal cord, retina such as a symptom of hyperactivity, convulsive, depressive disorder. In this research, Chitosan nanoparticles were used to prepare Glycine-CNP by adsorption of glycine and crosslinking of TPP (tripolyphosphate), and magnetic Glycine-Fe 3 O 4 -CNP was finally fabricated for applying to glycine delivery system. From the DLS and SEM analysis it was known the size of glycine-Fe 3 O 4 -CNP 191 nm and round circle shaped. FT-IR and XRD could show molecular bonding and its magnetic property. By Ninhydrin test optimal glycine releasing conditions were identified that pH 7~7.4, 95 o C, and 2 wt% of Nynhydrin. The maximum releasing ratio of glycine was 18.13% at the optimal condition