In vivo COX-2 modulation and metabolite profiling of Pandanus tectorius leaves extracts
DC Field | Value | Language |
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dc.contributor.author | del Mundo, Crisfel R. | - |
dc.contributor.author | Castillo, Agnes L. | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Tan, Mario A. | - |
dc.date.available | 2020-04-06T06:37:57Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 2190-572X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26103 | - |
dc.description.abstract | The Pandanus tectorius methanolic (PTM) and P. tectorius aqueous (PTA) extracts were investigated for their potential in vivo anti-inflammatory activity using carrageenan-induced rat paw edema. Parameters including paw thickness measurement, histopathological, and immunohistochemical cyclooxygenase (COX)-2 expression analyses were measured and analyzed. PTA at 500 mg/kg significantly reduced inflammation after induction of carrageenan (Carr), with mean paw thickness change of 0.110 +/- 0.024 mm at sixth hour post-induction and histopathological mean inflammatory grade of 1.80 +/- 0.20. The reduced immunohistochemical COX-2 expression using PTA at 500 mg/kg was determined with mean final 3,3 '-diaminobenzidine (DAB) intensity of 63.70 +/- 2.08. The profiling of metabolites by liquid chromatography-mass spectrometry (LC-MS) revealed presence of ethyl caffeate and dihydroconiferyl alcohol as putative secondary metabolites of PTA which were the major peaks and have been reported to possess anti-inflammatory activities. This research has provided scientific insights of utilizing P. tectorius as a potential anti-inflammatory agent containing secondary metabolites which may be pharmacologically relevant. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.relation.isPartOf | 3 BIOTECH | - |
dc.title | In vivo COX-2 modulation and metabolite profiling of Pandanus tectorius leaves extracts | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000513551000006 | - |
dc.identifier.doi | 10.1007/s13205-020-2087-8 | - |
dc.identifier.bibliographicCitation | 3 BIOTECH, v.10, no.3 | - |
dc.identifier.scopusid | 2-s2.0-85079015376 | - |
dc.citation.title | 3 BIOTECH | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.contributor.affiliatedAuthor | Tan, Mario A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Pandanus tectorius | - |
dc.subject.keywordAuthor | Cyclooxygenase | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | CARRAGEENAN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FRUITS | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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