Enhanced Bidirectional Connectivity of the Subthalamo-pallidal Pathway in 6-OHDA-mouse Model of Parkinson's Disease Revealed by Probabilistic Tractography of Diffusion-weighted MRI at 9.4T
- Authors
- Kim, A-Yoon; Oh, Chiwoo; Im, Hyung-Jun; Baek, Hyeon-Man
- Issue Date
- Feb-2020
- Publisher
- KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
- Keywords
- Basil ganglia; Parkinsons disease; Diffusion MRI; Probabilistic tractography; Globus pallidus; Subthalamic nucleus
- Citation
- EXPERIMENTAL NEUROBIOLOGY, v.29, no.1, pp.80 - 92
- Journal Title
- EXPERIMENTAL NEUROBIOLOGY
- Volume
- 29
- Number
- 1
- Start Page
- 80
- End Page
- 92
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26144
- DOI
- 10.5607/en.2020.29.1.80
- ISSN
- 1226-2560
- Abstract
- An important challenge in Parkinson's disease (PD) based neuroscience and neuroimaging is mapping the neuronal connectivity of the basal ganglia to understand how the disease affects brain circuitry. However, a majority of diffusion tractography studies have shown difficulties in revealing connections between distant anatomic brain regions and visualizing basal ganglia connectome. In this current study, we investigated the differences in basal ganglia connectivity between 6-OHDA induced ex-vivo PD mouse model and normal ex-vivo mouse model by using diffusion tensor imaging tractography from diffusion-weighted images obtained with a high resolution 9.4 T MR scanner. Connectivity pattern of the basal ganglia were compared between five 6-OHDA and five control ex-vivo mouse brains using results of probabilistic tractography generated with PROBTRACKX. When compared with control mouse, 6-OHDA mouse showed significant enhancements to motor territory-related subthalamopallidal and pallido-subthalarnic connectivity Multi-fiber tractography combined with diffusion MRI data has the potential to help recognize the abnormalities found in connectivity of psychiatric and neurologic disease models.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 보건과학대학 > 의용생체공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26144)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.