Implications of specific gene expression patterns in enamel knot in tooth developmentImplications of specific gene expression patterns in enamel knot in tooth development
- Other Titles
- Implications of specific gene expression patterns in enamel knot in tooth development
- Authors
- 김태영; Sanjiv Neupane; Yam Prasad Aryal; 이의선; 김지연; 서조영; 이영균; 손원주; 안서영; 하정홍; 안창현; 김재영
- Issue Date
- Mar-2020
- Publisher
- 대한구강생물학회
- Keywords
- Mice; Molar; Genes; Epithelium; Embryonic development
- Citation
- International Journal of Oral Biology, v.45, no.1, pp.25 - 31
- Journal Title
- International Journal of Oral Biology
- Volume
- 45
- Number
- 1
- Start Page
- 25
- End Page
- 31
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26304
- ISSN
- 1226-7155
- Abstract
- Enamel knot (EK)—a signaling center—refers to a transient morphological structure comprising epithelial tissue.
EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26 , Fat4, Meis2, Sln , and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.
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